Infinium Omni2.5Exome-8 Kit

Comprehensive coverage and functional exonic content for next-generation genotyping, GWAS, and CNV analysis.Read More...
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Infinium™ Omni2.5Exome-8 v1.4 Kit (16 samples)

20024552

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Infinium™ Omni2.5Exome-8 v1.4 Kit (48 samples)

20024553

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Infinium™ Omni2.5Exome-8 v1.4 Kit (96 samples)

20024554

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Infinium™ Omni2.5Exome-8 v1.4 Kit (384 samples)

20024555

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Product Highlights

The Infinium Omni2.5Exome-8 BeadChip array delivers comprehensive coverage of common, rare, and exonic SNP content from the 1000 Genomes Project (1kGP)1, providing maximum genomic information of diverse world populations. With combined markers from the Infinium Omni2.5-8 Kit and Infinium Exome-24 Kit, the Infinium Omni2.5Exome-8 BeadChip is a powerful tool for next-generation genotyping and genome-wide association studies (GWAS).

Using the proven iScan System and integrated analysis software, these eight-sample BeadChips offer high throughput, optimized tag SNPs, functional exonic content, and fully supported copy number variation (CNV) analysis. Combined with convenient packaging and a streamlined PCR-free protocol, the Infinium Omni2.5Exome-8 BeadChip Kits provide a optimized DNA analysis solution.

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Specifications

Product Comparison

Infinium Omni2.5Exome-8 Kit Infinium Exome-24 Kit Infinium CoreExome-24 Kit Infinium OmniExpressExome-8 Kit Infinium Omni5Exome-4 Kit
Automation Capability Automated Array Loader, Liquid Handling Robots Automated Array Loader, Liquid Handling Robots Automated Array Loader, Liquid Handling Robots Automated Array Loader, Liquid Handling Robots Automated Array Loader, Liquid Handling Robots
Description Combines >2.5 million tag SNPs from the HapMap and 1000 Genomes projects (>2.5%MAF) with >240,000 markers from the Infinium Exome-24 BeadChip array, to enable genome-wide variation studies while maximizing coverage of functional exonic SNPs. Study putative functional exonic variants that consist of >240,000 markers representing European, African, Chinese, and Hispanic individuals, and a range of common conditions, from type 2 diabetes to cancer, psychiatric disorders, and more. Includes all of the tag SNPs found on the Infinium Core-24 BeadChip, plus over 240,000 markers from the Infinium Exome-24 BeadChip, with the capacity to add up to 100,000 semi-custom markers for economical large-scale genotyping studies. Offers over 274,000 functional exonic markers while delivering high coverage of putative functional exonic variants selected from over 12,000 individual exome and whole-genome sequences, for studying novel associations with traits and diseases. A high-density array that provides coverage of common, intermediate, and rare SNPs using functional exonic content, for genome-wide genotyping and copy number variation studies.
Number of Markers Fixed markers: 2,608,742, Custom marker add-on capacity: None Fixed markers: 244,883, Custom marker add-on capacity: Up to 400,000 (with + kit versions) Fixed markers: 550,601, Custom marker add-on capacity: Up to 100,000 (with + kit versions) Fixed markers: 958,497, Custom marker add-on capacity: Up to 30,000 Fixed markers: 4,548,474, Custom marker add-on capacity: None
Number of Samples 8 samples per array 24 samples per array 24 samples per array 8 samples per array 4 samples per array
Sample Throughput ~1067 samples per week (estimate for 2 iScan Systems, 1 AutoLoader 2.x, 2 Tecan robots, and a 5-day work week) ~2304 samples per week (estimate for 1 iScan System, 1 AutoLoader 2.x, 2 Tecan robots, and a 5-day work week) ~2304 samples per week (estimate for 1 iScan System, 1 AutoLoader 2.x, 2 Tecan robots, and a 5-day work week) ~960 samples per week (estimate for 2 iScan Systems, 1 AutoLoader 2.x, 2 Tecan robots, and a 5-day work week) ~544 samples per week (estimate for 2 iScan Systems, 1 AutoLoader 2.x, 3 Tecan robots, and a 5-day work week)
Species Category Human Human Human Human Human

Method-Specific Workflow Example

 

Case Studies

The Pharmacogenetics of Cardiovascular Disease Therapy

Dr. Marie-Pierre Dube and researchers at the Montreal Heart Institute used the Infinium HumanOmni2.5Exome BeadChip to identify responder genotypes in a failed cholesterol drug (dalcetrapib) trial.

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Scanning Population-Based Biobanks to Identify a Rare Gene Variant for Myocardial Infarctions

The HUNT Biobank and Lifandis AS provide access to biological samples and corresponding clinical data from more than 250,000 individuals in the Norwegian population using Illumina off-the-shelf and custom Infinium HumanExome BeadChips.

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The HumanOmni2.5Exome-8 BeadChip Kit has been renamed to Infinium Omni2.5Exome-8 Kit. Kits with either name on the label contain the same quality reagents and follow the same workflow.

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