The Infinium Global Diversity Array with Cytogenetics-8 is a scalable, cost-effective microarray that contains approximately 1.8M probes, with 160K probes supplementing the current Global Diversity Array manifest across more than 4800 tiered genes. Supplemental probes were selected based on the input from a cytogenetics research consortium and strategically localized near exons, in spatial consideration of existing probe placement, to deliver optimal performance in copy number variation analysis.
Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB for research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.
| Infinium Global Diversity Array with Cytogenetics-8 | Infinium Global Diversity Array-8 Kit | Infinium CytoSNP-850K v1.3 BeadChip | |
|---|---|---|---|
| Assay Time | 3 days | 3 days | |
| Automation Capability | Automated Array Loader, Liquid Handling Robots | Automated Array Loader, Liquid Handling Robots | Automated Array Loader, Liquid Handling Robots |
| Cancer Type | Hematologic, Solid Tumor | Hematologic, Solid Tumor | Hematologic, Solid Tumor |
| Description | The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. | The 8-sample Infinium Diversity Array provides targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. | The 8-sample Infinium CytoSNP-850K v1.2 BeadChip provides disease-focused coverage of 3262 genes of known cytogenetics relevance in both constitutional and cancer applications. The BeadChip content includes approximately 850K empirically selected variant markers spanning the genome with supplemental coverage for cytogenetic applications. |
| Hands-On Time | 1 hour and 5 minutes for automated 8-beadchip workflow | 1 hour 5 min. for automated 8-beadchip workflow, 6 hours 15 min. for manual 8-beadchip workflow | |
| System Compatibility | iScan | iScan | iScan, NextSeq 550 |
| Technology | Microarray | Microarray | Microarray |
| Variant Class | Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs) | Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs) | Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs) |
The Infinium™ Global Diversity Array with Cytogenetics-8 BeadChip provides accurate analysis of gene structure and numerical variation
Read MoreCytogenetic Analysis by High-Resolution SNP Array
Application Note | PDF 2 MB
Custom Cluster File Creation for Improved Copy Number Analysis
Technical Note | PDF < 1 MB
Data Sheet | PDF | 5 versions
Custom Protocol Selector
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