The Infinium Global Screening Array-24 with Cytogenetics-24 v1.0 contains approximately 700K variants, including 80K supplemental probes targeting more than 4800 tiered genes and regions with known disease associations. Target variants were selected based on the input from a cytogenetics research consortium and include genes defined by ClinGen as pathogenic and likely pathogenic along with an enhanced backbone for a modern, up-to-date assay.
Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB for research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.
Infinium Global Screening Array with Cytogenetics-24 | Infinium Global Diversity Array with Cytogenetics-8 | |
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Assay Time | 3 days | 3 days |
Automation Capability | Automated Array Loader, Liquid Handling Robots | Automated Array Loader, Liquid Handling Robots |
Cancer Type | Hematologic, Solid Tumor | Hematologic, Solid Tumor |
Description | The 24-sample Infinium Global Screening Array with Cytogenetics-24 provides targeted coverage of more than 4800 key genes across the genome. Approximately 700K markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 2.5Mb. | The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb. |
Hands-On Time | 1 hour and 5 minutes for automated 8-beadchip workflow | 1 hour and 5 minutes for automated 8-beadchip workflow |
System Compatibility | iScan | iScan |
Technology | Microarray | Microarray |
Variant Class | Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs) | Chromosomal Abnormalities, Copy Number Variants (CNVs), Loss of Heterozygosity (LOH), Single Nucleotide Polymorphisms (SNPs) |
Cytogenetic Analysis by High-Resolution SNP Array
Application Note | PDF 2 MB
Custom cluster file creation for improved copy number analysis
Technical Note | PDF < 1 MB
Infinium Global Screening Array with Cytogenetics-24 v1.0 BeadChip
Data Sheet | PDF < 1 MB
Custom Protocol Selector
Generates customized, end-to-end instructions