Infinium Global Screening Array-48 Kit

The Global Screening Array-48 v4.0 Kit is a scalable, cost-effective solution designed to support high-volume genotyping studies.

Infinium Global Screening Array-48 Kit

The Global Screening Array-48 v4.0 Kit is a scalable, cost-effective solution designed to support high-volume genotyping studies.

- English
- Korean
- Japanese
Data sheet PDF < 1 MB

3 versions

~11,520

Sample throughput

48

Number of samples

~650K

Number of markers

See full details in the specifications table

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Overview
Applications
Documentation
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Overview

The Infinium Global Screening Array-48 v4.0 is our most advanced scalable and cost-effective solution for large-scale genomic studies.

48-sample BeadChip provides scalability advantages over 24-sample, Infinium Global Screening Array v3.0
Infinium Global Screening Array v4.0 includes environmentally friendly, formamide-free reagents
Infinium Global Screening Array v4.0 requires 100 ng of input DNA, requiring only half the input amount required for the Infinium Global Screening Array v3.0

Key features

Approximately 650K markers that span the human genome
48-sample BeadChip built for high-throughput laboratories
Automated, scalable workflow with a 2–2.5-day turnaround time
50K marker custom add-on capacity enables flexibility
BeadChips built on Infinium EX format compatible with powerful liquid handling instruments running most advanced software

Optimized global content

Genome-wide content in v4.0 includes variants with established disease associations, relevant pharmacogenomics markers, and curated exonic content derived from ClinVar, NHGRI, PharmGKB, and ExAC databases.

Widely adopted

Over 30 million samples of the Global Screening Array have been ordered by researchers, healthcare networks, consumer genomics companies, and genomic service providers.

Broad applications

Precision medicine research initiatives around the world use the Global Screening Array to study disease risk, stratify samples, and incentivize participation across a large variety of clinical applications.

Specifications

Automation capability	Liquid handling robots, Automated array loader
Input quantity	100 ng
Instruments	iScan System
Method	Genome-wide genotyping array
Nucleic acid type	DNA
Number of markers	Approximately 650K markers that span the human genome
Number of samples	48 samples/array
Sample throughput	~11,520 samples/week max throughput per iScan System. Throughput and scan times will vary based on system configuration.
Specialized sample types	Blood
Species category	Human
Technology	Microarray
Variant class	Single nucleotide polymorphisms (SNPs), Structural variants, Insertions-deletions (indels), Copy number variants (CNVs)

Required Products

The main difference between each Infinium Global Screening Array-48 Kit is the number of samples supported with the provided reagents. Select from kits with a “+” designation when custom content is needed for the array.

Customers will need the iScan System, Infinium Automated Pipetting System with ILASS, and an Infinium EX/XT Starter Kit 220V or Infinium EX/XT Starter Kit 110V.

The Infinium Amplification System is optional but can be added to enable automation of the pre-amplification steps in the workflow.

Standard Infinium accessories (e.g., Te-Flow chamber, hybridization oven, etc.)

/ Results

FAQ

You will need the following products:

iScan System
Infinium EX array kit, such as the Global Screening Array-48 v4.0 kit
Infinium Automated Pipetting System with ILASS, to be used for post-amplification steps
Infinium Amplification System (Optional), to be used to automate pre-PCR steps (WGA)
Infinium EX/XT starter kit

Throughput:

The ability to run 48 samples per BeadChip on Infinium Global Screening Array-48 Kit and scale up to 11,520 samples per week
iScan System with Infinium liquid handler instruments can scale up to hundreds of thousands of samples per year

Automation:
Illumina Lab Automation Software Solution (ILASS) guides the user through the steps of the workflow via an intuitive user interface and provides on-deck validation, meaning the consumables loaded on the liquid handling robots are verified prior to use regardless of whether the customer is using LIMS. Real-time integration with cloud-based Clarity LIMS supports compliance with eSignature capability, audit trails, reagent and lot tracking, preset protocols, and privacy and security controls, which is critical for high-throughput customers.

Whole-genome amplification step is 3 hr for Infinium EX compared with 24 hr for legacy Infinium workflows, reducing total workflow time by 20%
Input DNA required for Infinium EX genotyping workflow is 100 ng compared with 200 ng for legacy workflows
Reagents are EH&S-friendly and formamide free
ILASS provides an improved UI and support experience
Updated automation and software allow integration with cloud-based analysis

Both arrays feature a multiethnic genome-wide backbone with content for population studies, variant screening, and precision medicine research. In addition to this, Infinium Global Clinical Research Array-24 v1.0 covers additional clinical research markers from ACMG 73 and gnomAD exome to increase coverage of underrepresented populations.

/ Results

Applications

The Infinium Global Screening Array-48 4 is a powerful, efficient, and cost-effective BeadChip for population-scale genomic studies. Designed for an extensive range of applications, users can leverage flexible, customizable options while enjoying intuitive workflows.

Example workflow

Select content

Genotyping

Use cutting-edge genotyping techniques to explore a broad range of genetic variants and gain insight into disease etiology on a molecular level.

Process and scan arrays

iScan

The iScan microarray scanner supports high-throughput BeadChip processing, scanning hundreds to thousands of samples quickly and accurately.

Track, analyze, and report

DRAGEN Array

DRAGEN Array provides accurate, comprehensive and efficient secondary analysis for Infinium microarrays.

GenomeStudio Software

GenomeStudio software provides an integrated platform for data analysis of microarray-based genotyping assays, with a user-friendly graphical interface.

Documentation

Product literature

- English
- Korean
- Japanese
Data sheet PDF < 1 MB

3 versions

Support documentation

A dedicated support section is not currently available for this product

Compare

	Infinium Global Screening Array-48 Kit	Infinium Global Screening Array-24 Kit	Infinium Global Clinical Research Array-24 v1.0 Kit	Infinium Global Diversity Array-8 Kit
Automation capability	Liquid handling robots, Automated array loader	Liquid handling robots, Automated array loader	Liquid handling robots, Automated array loader	Liquid handling robots, Automated array loader
Input quantity	100 ng	200 ng	100 ng	200 ng DNA
Instruments	iScan System	iScan System	iScan System	iScan System
Method	Genome-wide genotyping array	High-throughput genotyping array, Genome-wide genotyping array		Genome-wide genotyping array
Nucleic acid type	DNA	DNA	DNA	DNA
Number of markers	Approximately 650K markers that span the human genome	654,027 fixed markers. Custom marker add-on capacity: Up to 100K.	Fixed markers: 1,157,992, Custom marker add-on capacity: Up to 50,000	1,825,277 fixed markers. Custom marker add-on capacity: Up to 175K.
Number of samples	48 samples/array	24 samples per array	24 samples per array	8 samples per array
Sample throughput	~11,520 samples/week max throughput per iScan System. Throughput and scan times will vary based on system configuration.	~5760 samples per week	~5760 samples per week	~1728 samples per week
Specialized sample types	Blood	Blood, FFPE tissue, Buccal swabs, Saliva	Blood	Blood, FFPE tissue, Buccal swabs, Saliva
Species category	Human	Human	Human	Human
Technology	Microarray	Microarray	Microarray	Microarray
Variant class	Single nucleotide polymorphisms (SNPs), Structural variants, Insertions-deletions (indels), Copy number variants (CNVs)	Single nucleotide polymorphisms (SNPs), Structural variants, Copy number variants (CNVs)		Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Structural variants, Copy number variants (CNVs)

Resources

Introducing the Infinium EX platform

The Infinium EX platform enables more comprehensive coverage of the genome and supports higher volume sample processing. The workflow includes components designed to work seamlessly together including EX BeadChips with expertly selected content, advanced automation, and DRAGEN Array secondary analysis software. Learn more about the accuracy, scalability, cost-effectiveness, and efficient workflow of the Infinium EX platform.

Fixed content (6)

Infinium Global Screening Array-48 v4.0 Kit (48 samples)

20065217

The Global Screening Array-48 v4.0 Kit, built on proven Infinium technology, offers exceptional coverage of key genome-wide clinical content, and provides a cost-effective and highly scalable workflow to support population-scale clinical research studies.

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Infinium Global Screening Array-48 v4.0 Kit (96 samples)

20068344

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Infinium Global Screening Array-48 v4.0 Kit (1152 samples)

20068345

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Infinium Global Screening Array-48+ v4.0 Kit (48 Samples)

20068360

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Infinium Global Screening Array-48+ v4.0 Kit (96 Samples)

20068361

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Infinium Global Screening Array-48+ v4.0 Kit (1152 Samples)

20068362

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Accessory products (4)

Infinium Automated Pipetting System with ILASS

20051293

This package supports customers who want to automate their Infinium processing using ILASS control software. It includes a cloud-based Clarity LIMS- ready Tecan Freedom EVO 150cm liquid handler with RoMA ARM equipped to run Post-AMP Infinium Assay protocols, robotic accessories and Robot Control Software. Cloud-based Clarity LIMS sold separately. NOTE: Only certain Infinium Assay Protocols can be run on ILASS. Also, instrument does not include the Te-Flow Rack/Water Circulator kit, which is required for the Infinium workflow and must be ordered separately (through a starter kit or by itself – P/N 20028404)

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Infinium Amplification System

20064466

This package supports customers who want to automate their Pre-AMP Infinium processing. It includes a cloud-based Clarity LIMS-ready Hamilton Star liquid handler equipped to run Pre-AMP Infinium Assay protocols, robotic accessories and ILASS control software. Cloud-based Clarity LIMS sold separately. NOTE: Only certain Infinium Assay Protocols can be run on ILASS.

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Infinium XT Starter Kit (24 Beadchip) 220V

20031992

Infinium XT Starter Kit (24 Beadchip) 220V

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Infinium XT Starter Kit (24 Beadchip) 110V

20031915

Infinium XT Starter Kit (24 Beadchip) 110V

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Infinium Global Screening Array-48 Kit

Infinium Global Screening Array-48 Kit

~11,520

48

~650K

Overview

Key features

Optimized global content

Widely adopted

Broad applications

Specifications

Required Products

What products do I need?

What accessories do I need?

FAQ

What is needed to implement the Infinium EX genotyping workflow?

What are the advantages of the Infinium EX platform?