Order the NovaSeq X Series
Advanced chemistry, optics, and informatics combine to deliver exceptional speed and data quality, outstanding throughput and scalability.
Predesigned, optimized panel to provide enhanced coverage of challenging-to-map regions within protein-coding genes using Illumina Complete Long Reads with Enrichment library prep kit. Analyzed in combination with a required ≥ 30× standard short-read whole genome.
Assay time
Hands-on time
Input quantity
The Illumina Human Comprehensive Panel focuses long reads where they provide the greatest value in the genome. Targeted long reads complement highly accurate short-read WGS, creating a comprehensive human whole-genome solution that delivers exceptional small variant accuracy with an F1 score of 99.87% (SNVs +Indels), as measured by the PrecisionFDA1 Truth Challenge v2 benchmarks.
Illumina Complete Long Read Prep with Enrichment and the Human Comprehensive Panel can help you achieve greater sample throughput than other long-read sequencing solutions when paired with Illumina platforms. Use to augment existing WGS data sets as a reflex tool for broader variant discovery.
The Illumina Human Comprehensive Panel enhances coverage in a broad set of genic regions that benefit from targeted long reads, within >6500 protein coding genes.2 In developing this panel, the full set of over 20,000 protein-coding genes were considered. Genes that are comprehensively covered by short reads alone were excluded. This panel is ready to ship and optimized for use with Illumina Complete Long Read Prep with Enrichment, Human.
Assay time | ~2 days |
---|---|
Automation capability | Liquid handling robots |
Description | Predesigned and optimized panel to address challenging-to-map regions within 6599 protein-coding genes. |
Hands-on time | ~6 hr |
Input quantity | 50 ng DNA recommended; as low as 10 ng DNA |
Instruments | NovaSeq X System, NovaSeq 6000Dx in Research Mode, NovaSeq 6000 System, NovaSeq X Plus System |
Mechanism of action | Tagmentation, Land-marking, Bead-linked transposome, Hybrid-capture chemistry |
Method | Targeted DNA sequencing, Long-read sequencing, Whole-genome sequencing, Target enrichment |
Multiplexing | Up to 64 samples |
Nucleic acid type | DNA |
Specialized sample types | Blood, Not FFPE-compatible, Low-input samples, Saliva |
Species category | Human |
Technology | Sequencing |
Variant class | Short tandem repeats (STRs), Single nucleotide polymorphisms (SNPs), Germline variants, Structural variants, Insertions-deletions (indels), Copy number variants (CNVs) |
Available to order panel alone or as part of a kit. Requires Illumina Complete Long Read Prep with Enrichment, Human (24 or 96 samples) and Illumina unique dual Indexes. Purchase sufficient iCredits to meet data storage and analysis needs based on throughput.
A standard short-read ≥ 30 × whole-genome library from the same sample is required for Illumina Complete Long Read with Enrichment data analysis. Illumina DNA PCR-Free Prep is recommended for library preparation of the standard short read whole genome. FASTQ files from a previously run sample can be used.
DRAGEN ICLR (Illumina Complete Long Read with Enrichment)
Instrument | Recommended number of samples | Read length |
---|---|---|
NovaSeq 6000 System | 24 samples per S4 flow cell, 10 samples per S2 flow cell, 4 samples per S1 flow cell, 2 samples per SP flow cell |
2 × 150 |
NovaSeq X System | 64 samples per 25B flow cell, 24 samples per 10B flow cell, 4 samples per 1.5B flow cell |
2 × 150 |
Human whole-genome sequencing provides the most detailed view into the complex genetic variants that make us unique.
Illumina Complete Long Read Technology
Illumina Complete Long Read technology powers a portfolio of assays that enable highly accurate long and short read sequencing on a single instrument.
Large whole-genome sequencing informs disease research and population genomics studies and reveals disease-associated alleles.
A dedicated support section is not currently available for this product
Illumina Complete Long Read Prep with Enrichment and the Human Comprehensive Panel help enhance coverage in challenging genic regions to complement standard short-read human WGS. IGV plot of STRC sequenced using standard short-read WGS and Illumina Complete Long Reads with enrichment.
Illumina Complete Long Read Prep with Enrichment and the Human Comprehensive Panel help enhance coverage in challenging genic regions to complement standard short-read human WGS. IGV plot of NEB sequenced using standard short-read WGS and Illumina Complete Long Reads with enrichment.
False negative (FN) plus false positive (FP) variant calls for SNPs and indels in genic regions targeted by the Human Comprehensive Panel, using Illumina Complete Long Read Prep with Enrichment (orange) compared to standard short-read WGS (blue).
Illumina Complete Long Read Prep with Enrichment, Human (24 samples)
20113832
A library preparation and enrichment solution for long-read human whole- genome sequencing (WGS) applications
Illumina Complete Long Read Prep with Enrichment, Human (96 samples)
20113833
A library preparation and enrichment solution for long-read human whole- genome sequencing (WGS) applications.
Illumina Complete Long Read Prep with Enrichment, Human Comprehensive Panel (24 samples)
20113834
A library preparation and enrichment solution with a probe panel designed to address regions that will benefit long-read human whole- genome sequencing (WGS) applications
Illumina Complete Long Read Prep with Enrichment, Human Comprehensive Panel (96 samples)
20113835
A library preparation and enrichment solution with a probe panel designed to address regions that will benefit long-read human whole- genome sequencing (WGS) applications
Illumina Complete Long Read Prep with Enrichment, HCP-24, S4 Starter Pack
20113838
This package contains 1 ICLR ENR-24 sample kit, 1 HCP-24, 1 NovaSeq 6000 S4 (300) cyc kits, and support 24 samples
Illumina Complete Long Read Prep with Enrichment, HCP-24, 10B Starter Pack
20113839
This package contains 1 ICLR ENR-24 sample kit, 1 HCP-24, 1 NovaSeq X 10B (300) cyc kit, and support for 24 samples
Illumina Human Comprehensive Panel (24 samples)
20113836
A hybridization capture probe panel designed to target regions of the human genome that will benefit long-read whole-genome sequencing (WGS) applications
Illumina Human Comprehensive Panel (96 samples)
20113837
A hybridization capture probe panel designed to target regions of the human genome that will benefit long-read whole-genome sequencing (WGS) applications
Illumina® Unique Dual Indexes, LT (48 Indexes, 48 Samples)
20098166
Illumina® Unique Dual Indexes, LT (48 Indexes, 48 Samples)
Illumina® DNA/RNA UD Indexes Set A, Tagmentation (96 Indexes, 96 Samples)
20091654
Illumina® DNA/RNA UD Indexes Set A, Tagmentation (96 Indexes, 96 Samples) Includes 96, 10 bp indexes sufficient for labeling 96 samples. Purchase library prep and enrichment reagents and probe panels separately.
List Price:
Discounts:
Illumina® DNA/RNA UD Indexes Set B, Tagmentation (96 Indexes, 96 Samples)
20091656
Illumina® DNA/RNA UD Indexes Set B, Tagmentation (96 Indexes, 96 Samples) Includes 96, 10 bp indexes sufficient for labeling 96 samples. Purchase library prep and enrichment reagents and probe panels separately.
List Price:
Discounts:
Illumina® DNA/RNA UD Indexes Set C, Tagmentation (96 Indexes, 96 Samples)
20091658
Illumina® DNA/RNA UD Indexes Set C, Tagmentation (96 Indexes, 96 Samples) Includes 96, 10 bp indexes sufficient for labeling 96 samples. Purchase library prep and enrichment reagents and probe panels separately.
List Price:
Discounts:
Illumina® DNA/RNA UD Indexes Set D, Tagmentation (96 Indexes, 96 Samples)
20091660
Illumina® DNA/RNA UD Indexes Set D, Tagmentation (96 Indexes, 96 Samples) Includes 96, 10 bp indexes sufficient for labeling 96 samples. Purchase library prep and enrichment reagents and probe panels separately.
List Price:
Discounts:
Illumina Analytics - 1 iCredit
20042038
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
List Price:
Discounts:
Illumina Analytics Starter Pack - 1,000 iCredits
20042039
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
List Price:
Discounts:
Illumina Analytics - 5,000 iCredits
20042040
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
List Price:
Discounts:
Illumina® DNA PCR-Free Prep, Tagmentation (24 Samples)
20041794
Includes reagents and Illumina Purification Beads for preparing 24 libraries. Purchase index adapters separately.
List Price:
Discounts:
Illumina® DNA PCR-Free Prep, Tagmentation (96 Samples)
20041795
Includes reagents and Illumina Purification Beads for preparing 96 libraries. Purchase index adapters separately.
List Price:
Discounts:
Showing of
Product
Qty
Unit Price
Product
Catalog ID
Quantity
Unit price
Reach out for information about our products and services, or get answers to questions about our technology.
Your email address is never shared with third parties.