Illumina Human Comprehensive Panel

Predesigned, optimized panel to provide enhanced coverage of challenging-to-map regions within protein-coding genes using Illumina Complete Long Reads with Enrichment library prep kit. Analyzed in combination with a required ≥ 30× standard short-read whole genome. Read More...
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Illumina Complete Long Read Prep with Enrichment, Human (24 samples)

20113832

Illumina Complete Long Read Prep with Enrichment, Human (96 samples)

20113833

Illumina Complete Long Read Prep with Enrichment, Human Comprehensive Panel (24 samples)

20113834

Illumina Complete Long Read Prep with Enrichment, Human Comprehensive Panel (96 samples)

20113835

Illumina Complete Long Read Prep with Enrichment, HCP-24, S4 Starter Pack

20113838

Illumina Complete Long Read Prep with Enrichment, HCP-24, 10B Starter Pack

20113839

Illumina Human Comprehensive Panel (24 samples)

20113836

Illumina Human Comprehensive Panel (96 samples)

20113837

Index Adapters

Illumina Unique Dual Indexes, LT (48 indexes, 48 samples)

20098166

Illumina® DNA/RNA UD Indexes Set A, Tagmentation (96 Indexes, 96 Samples)

20091654

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Illumina® DNA/RNA UD Indexes Set B, Tagmentation (96 Indexes, 96 Samples)

20091656

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Illumina® DNA/RNA UD Indexes Set C, Tagmentation (96 Indexes, 96 Samples)

20091658

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Illumina® DNA/RNA UD Indexes Set D, Tagmentation (96 Indexes, 96 Samples)

20091660

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Data Analysis & Storage

Illumina Analytics - 1 iCredit

20042038

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Illumina Analytics  Starter Pack - 1,000 iCredits

20042039

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Illumina Analytics  - 5,000 iCredits

20042040

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What accessories do I need?
What accessories do I need?

Illumina® DNA PCR-Free Prep, Tagmentation (24 Samples)

20041794

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Illumina® DNA PCR-Free Prep, Tagmentation (96 Samples)

20041795

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Product Highlights

The Illumina Human Comprehensive Panel focuses long reads where they provide the greatest value in the genome. Targeted long reads complement highly accurate short-read WGS, creating a comprehensive human whole-genome solution that delivers exceptional small variant accuracy with an F1 score of 99.87% (SNVs +Indels), as measured by the PrecisionFDA Truth Challenge v2 benchmarks.

Cost-effective and focused long reads

Illumina Complete Long Read Prep with Enrichment and the Human Comprehensive Panel can help you achieve greater sample throughput than other long-read sequencing solutions when paired with Illumina platforms. Use to augment existing WGS data sets as a reflex tool for broader variant discovery.

Comprehensive and optimized probe panel

The Illumina Human Comprehensive Panel enhances coverage in a broad set of genic regions that benefit from targeted long reads, within >6500 protein coding genes.2 In developing this panel, the full set of over 20,000 protein-coding genes were considered. Genes that are comprehensively covered by short reads alone were excluded. This panel is ready to ship and optimized for use with Illumina Complete Long Read Prep with Enrichment, Human.

  • Highly optimized panel designed to enhance coverage of challenging-to-map areas within protein-coding regions of the genome
  • Broad panel addressing > 6500 genes targeting a total of > 90 Mb using Illumina Complete Long Reads to address regions of low coverage

References

  1. PrecisionFDA. Truth Challenge V2: Calling Variants from Short and Long Reads in Difficult-to-Map Regions. https://precision.fda.gov/challenges/10
  2. Bekritsky MA, Colombo C, Eberle MA. Identifying Genomic Regions with High Quality Single Nucleotide Variant Calling. illumina.com/science/genomics-research/articles/identifying-genomic-regions-with-high-quality-single-nucleotide-.html

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Specifications

Project Recommendations

Instrument Recommended Number of Samples Read Length
NovaSeq 6000 System 24 samples per S4 flow cell, 10 samples per S2 flow cell, 4 samples per S1 flow cell, 2 samples per SP flow cell
A paired PCR-free WGS library is required for analysis (Illumina DNA PCR-Free Prep recommended)
2 × 150
NovaSeq X System 64 samples per 25B flow cell, 24 samples per 10B flow cell, 4 samples per 1.5B flow cell
A paired PCR-free WGS library is required for analysis (Illumina DNA PCR-Free Prep recommended)
2 × 150

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Product Literature

Manuals and Support Information

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